ACTIVE SUBSTANCE

Abobotulinumtoxina Acarbose Adalimumab Adipotide Albuterol Alpha-Melanocyte Alfuzosin Amiodarone Amlodipine Amoxycillin Amoxycillin Clavulanate Amoxycillin Trihydrate Anastrozole Anti-Obesity Drug-9604 Atorvastatin Avanafil Azithromycin Baclofen Bacteriostatic Water Betamethasone Betahistine Betamethasone valerate Bimatoprost Boldenone Undecylenate BPC-157 Bremelanotide Bromocriptine Cabergoline Candesartan Cilexetil Cefalexin Cefdinir Cefixime Cefuroxime Ciprofloxacin Chlorodehydro Methyltest Clarithromycin Clenbuterol Clobetasol Propionate Clomiphene Citrate Clopidogrel Colecalciferol Cyproterone Dabigatran Dapoxetine Delta sleep-inducing peptide Desloratadine Diclofenac Potassium Dihydroboldenone Cypionate Diosmina Donnazyme Doxazosin Doxycycline Hyclate Drospirenone Drostanolone Di-Propionat Drostanolone Enanthate Drostanolone Propionate Duloxetine Dutasteride Dydrogesterone ED & PE Mixes Enoxaparin Sodium Epitalon Erythropoietin Esomeprazole Etanercept Ethinyl Estradiol Examorelin Exemestane Finasteride Flibanserin Fluoxetine Fluoxymesterone Fluticasone Furosemide Gemifloxacin Mesylate GHRH Peptide GHRP Peptide Ginseng Gliclazide Gonadorelin Growth Hormone peptide fragment 176-191 GW1516 Herbal Mix Hesperidina Human Chorionic Gonadotropin Human Menopausal Gonadotropin Human Insulin Hyaluronic acid Hydrochloride Hydrochlorothiazide Hydroquinone Hydroxychloroquine Hydroxyzine Ibuprofen IGF-1LR3 Imiquimod Immune globulin Insulin Insulin Glargine Insulin Glulisine Insulin Isophane Insulin Lispro Insulin Lispro Protamine Suspension Ipamorelin Ipratropium Bromide Isotretinoin Ketotifen L-Ornithine L-Aspartate Lacidipine Lansoprazole Leflunomide Letrozole Levofloxacin Lidocaine Losartan Levothyroxine Sodium Liothyronine Sodium Lisinopril Mebeverine Hydrochloride Mechano Growth Factor Melanocyte-stimulating hormone (MSH) Mesterolone Metformin Metformin Hydrochloride Methandienone Methenolone Acetate Methenolone Enanthate Methimazole Methyl-1- Testosterone Methyldrostanolone Methyltrienolone Metoprolol Metronidazole Miconazole Nitrate Montelukast Sodium Moxifloxacin Multivitamin Nandrolone Decanoate Nandrolone Phenylpropionate Nandrolone Propionate Nandrolone Undecanoate Onabotulinumtoxina Orlistat Oxandrolone Oxymetholone Oxytocin Pimecrolimus Pioglitazone Pegylated Mechano Growth Factor Penicillin Perindopril Arginine Prednisolone Pregabalin Pyridostigmine Pyridoxine Raloxifene Retinoic Acid Rho(D) immune globulin Rivaroxaban Rosuvastatin Safed Musli Salmeterol Selank Semax Sibutramine Sildenafil Silymarin Sitagliptin Sodium Hyaluronate Sodium fusidat Solifenacin Somatropine - 191 Amino Acid Spiramycin Spironolactone Stanozolol Stanozolol Suspension T3 Triiodothyronine Tadalafil Tamoxifen Citrate Telmisartan Testosterone Acetate Testosterone Base Testosterone Cypionate Testosterone Decanoate Testosterone Enanthate Testosterone Gel Testosterone Isocaproate Testosterone Phenylpropionate Testosterone Propionate Testosterone Suspension Testosterone Undecanoate Thiamine Thiocolchicoside Thymosin beta-4 Ticagrelor Tioconazole Tiotropium bromide Tolterodine Toremifene Citrate Trenbolone Acetate Trenbolone Base Trenbolone Blend Trenbolone Enanthate Trenbolone Hexahydrobenzylcarbonate Trenbolone Suspension Triamterene Hydrochlorothiazide Triptorelin Udenafil Ursodeoxycholic acid Valacyclovir Valproic Acid Valsartan Vardenafil Varenicline Vitamin A Vitamin B1 Vitamin B2 Vitamin B3 Vitamin B5 Vitamin B6 Vitamin B9 Vitamin B12 Vitamin C Vitamin D Vitamin E Vitamin K1 Yohimbine Zinc Sulfate

discreet

ANAZOLE

Customer Reviews Shipping options
$38.00

Characteristics

ACTIVE HALF-LIFE
2 days
Classification
Non-steroidal aromatase inhibitor
Dosage
0.5-1 mg/day
ACNE
No
WATER RETENTION
No
HBR
No
HEPATOTOXICITY
No
AROMATIZATION
No
Active Substance
FORM
30 pills x 1 mg
Manufacturer

Description

 

 

  • Chemical name: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
  • Formula: C17H19N5
  • Anabolic activity index: not a steroid
  • Androgenic activity index: not a steroid

 

 

ANAZOLE 1mg - ALPHA PHARMA

 

Alpha-Pharma Anazole (Anastrozole 1 mg) belongs to a category and class of drugs known as aromatase inhibitors (AIs). Aromatase inhibitors belong to an even broader class of drugs known as anti-estrogens. The other subcategory of drug under the anti-estrogens category is known as selective estrogen receptor modulators (SERMs), such as Altamofen (Nolvadex) and Promifen (Clomid). AIs and SERMs make up anti-estrogens. Aromatase inhibitors differ greatly from SERMs in their action and how they deal with the issues of estrogen control. The misunderstanding that SERMs, such as Altamofen (Nolvadex) and Promifen (Clomid), serve to lower estrogen levels must first be addressed. This is a persistent rumor among the anabolic steroid using community that has begun to erode as of late, but the rumor still persists. SERMs serve to block the action of Estrogen at the receptor sites in breast tissue by occupying the receptor sites in place of Estrogen so that Estrogen itself cannot exert its effects there through receptor site binding. Conversely, SERMs will also act as Estrogens at receptor sites at other cells in other areas of the body (the liver, for example in Altamofen (Nolvadex)’s case). SERMs do not lower circulating levels of Estrogen in blood plasma. Aromatase inhibitors serve to do this by eliminating the production of Estrogen through binding to and disabling the aromatase enzyme, which is the enzyme responsible for the conversion (or aromatization) of androgens into Estrogen.

Anazole is used among breast cancer treatments as what is known as an adjunct treatment. This usually refers to an additional treatment when other standard treatments have failed to meet proper expectations. Prior to the development and release of Anazole as a breast cancer treatment medication, the primary medication utilized for treatment for decades prior was Altamofen (Nolvadex) (Tamoxifen). Altamofen (Nolvadex) is considered to be utilized as the first and standard treatment for breast cancer patients. When Altamofen (Nolvadex) treatment, for one reason or another, fails to meet expectations during breast cancer treatment, second-line adjunct drugs such as Anazole are utilized.

One such study on Anazole on over 9,000 post-surgery female breast cancer patients observed its efficiency in comparison to Altamofen (Nolvadex) (both alone as well as both utilized simultaneously), resulting in far more favorable outcomes for Anazole over Altamofen (Nolvadex). The study, which was performed in 2002, concluded that Anazole was far more effective at cancer regression, as well as increasing the survival rate of the breast cancer patients following treatment. It was then this study (as well as others) that then of course prompted individuals among the anabolic steroid using community to take notice of it and begin investigating the benefits of its effects on strong Estrogen levels suppression. A study conducted later on demonstrated that the risk of recurrence of breast cancer was eliminated by 40% with Anazole use, but the patients experienced an increase in bone fractures. This is because Estrogen plays a central role in the proper maintenance of bone and its mineral retention, and this will become significantly reduced following the vast reduction of Estrogen levels resultant of Anazole administration.

Because Anazole was the very first aromatase inhibitor for many bodybuilders to have taken notice of, it is the most popular aromatase inhibitor used among anabolic steroid users for the purpose of Estrogen control. The use among anabolic steroid using athletes is for the control of almost all Estrogen-related side effects: the manifestation of gynecomastia, water retention and bloating, rising blood pressure (as a result of water retention increases from Estrogen). This is in contrast with SERMs such as Altamofen (Nolvadex), which only serve to block gynecomastia. Studies have in fact demonstrated that Anazole use in males has been effective enough to reduce circulating blood plasma levels of Estrogen by 50% at only a dose of 0.5 – 1mg daily. This is a very considerable decrease in men, but can be seen as quite different from the 80% reduction in female breast cancer patients, but it must be remembered that Estrogen and how it relates to the female physiology is different from males.

Aside from the use in bodybuilders, Anazole has also been medically used in males as well. Some males exhibit abnormally high Estrogen levels of many different reasons and Anazole has been utilized in order to combat these ailments. In particular, Anazolehas been used to treat male adolescents that exhibit excessive Estrogen levels during purberty, resulting in unwanted pubertal gynecomastia. In addition, excessive Estrogen levels in adolescent males during puberty can often result in stunted growth due to the fact that Estrogen plays a key role in fusing the growth plates of the bones shut, preventing any further linear growth, and Anazole has also been used to treat these conditions as well.


Anazole’s effects on serum Estrogen level control can be quite drastic even at a dose of 1mg daily. The amount of Estrogen suppression resulting from this dose has been demonstrated to be over 80% in patients. Anazole can be so effective at inhibiting the aromatase enzyme and thereby reducing Estrogen levels that this compound is typically only administered to post-menopausal females, and/or utilized when other first-line treatments for breast cancer has failed.

Anazole and Letrozole are both classified as non-steroidal and non-suicidal aromatase inhibitors that compete with the substrate for binding to the enzyme active site. This is very different from Aromasin (Exemestane), which is a steroidal and suicidal aromatase inhibitor that acts as a mechanism-based steroidal inhibitor that mimics the substrate, is converted by the enzyme to a reactive intermediate, and results in the inactivation of the aromatase enzyme . For ease of understanding, what this means to the layman is that Aromasin’s chemical structure resembles the traditional ‘targets’ that aromatase binds to (Testosterone, for example) and that it essentially ‘fools’ the aromatase enzyme into binding with it, only to become inhibited/deactivated. Because the binding strength is so great, this inhibition becomes permanent for the aromatase enzyme that Aromasin has become bound to. Anazole and Letrozole, being non-suicidal aromatase inhibitors, both compete with the enzyme’s traditional ‘targets’ rather than being assured a permanent spot (which is the advantage that Aromasin has over the other two).

Bodybuilders and athletes utilizing anabolic steroids will usually favor aromatase inhibitors such as Anazole for its ability to eliminate rising Estrogen levels at its root cause: aromatase. By disabling the aromatase enzyme, supraphysiological levels of aromatizable androgens (such as Testosterone, Dianabol, Boldenone, etc.) cannot convert into Estrogen, thereby eliminating any possible risk of Estrogen-related side effects.

Customer Reviews


Prince James
26.07.2018
Rating: EXCELLENT
Verified Purchase
Product arrived in 2 weeks to the US

product is exactly as discribed and I will be ordering a lot more from pharacom thank you so much for having such good shipping methods and great tracking info
Back to top