Alpha-Pharma Oxydrolone (aka Anadrol, Oxymetholone 50 pills x 50mg) is known (sometimes notoriously) as being one of the contenders for being the strongest oral anabolic steroid commercially available. It closely competes with Dianabol (Methandrostenolone), and steroid-using bodybuilding circles have always debated which of the two are stronger. Oxydrolone is the brand and trade name for the anabolic steroid more formally known as Oxymetholone. This is not to be confused with Oxandrolone, which is otherwise known as Anavar. Oxymetholone is Oxydrolone. Oxydrolone’s details were first released in 1959. Almost immediately after, the pharmaceutical company Syntex sold Oxymetholone under the name Oxydrolone-50 while Parke Davis & Co. also manufactured it, though they did so under the Androyd trade name. After its initial release onto prescription markets, Oxydrolone was quickly prescribed and used for a multitude of medical conditions ranging from geriatric atrophy to combating infections. It’s most noted and popular use as a medication, however, was in the treatment of anemia. Oxydrolone was prescribed here to increase the red blood cell count and hemoglobin levels of the anemic individual.
This was because of Oxydrolone’s ability to stimulate erythropoiesis at a very high rate. Although all anabolic steroids exhibit this capability, Oxydrolone’s ability to stimulate erythropoiesis far exceeds that of any other anabolic steroid. In these cases, Oxydrolone has been shown in studies to increase red blood cell production by a factor of 5 fold. As far as its general effectiveness as an anabolic steroid for muscle-building purposes is concerned, studies have demonstrated that it has exerted notable anabolic effects on muscle-wasting AIDS patients, causing them to actually gain 8kg of weight while those who were administered a placebo not only lost weight but also experienced an increase in mortality. It is for this reason that Oxydrolone tends to be prescribed almost primarily in this day and age for AIDS patients and muscle wasting diseases.
One of the unique and mysterious characteristics possessed by Oxydrolone is that although it is a derivative of DHT, it possesses a very high level of Estrogenic activity. It is typically known that DHT-derivative anabolic steroids should be unable to convert into Estrogen via the aromatase enzyme and therefore elicit no Estrogenic effects, but this is very different with Oxydrolone. Oxydrolone is well known for causing water retention, bloating, gynecomastia, and other Estrogenic effects on the body even though it does not convert into Estrogen. It is believed that Oxydrolone itself acts as an estrogen in certain tissues. This will be further expanded upon and discussed later on, but it is imperative for any potential user to understand that first and foremost that although Oxydrolone is a DHT-derivative, one will not experience the lean hard gains typically seen with DHT-derivatives. Oxydrolone is notorious for its Estrogenic effects that cannot be combated with aromatase inhibitors due to its inability to convert into Estrogen.
Oxydrolone is an orally active anabolic steroid, which means it has been C17 Alpha Alkylated in order to allow the anabolic steroid to make the first pass through the liver without suffering destruction through liver metabolism. Oxydrolone, however, is very well known for its very harsh hepatotoxicity, which will be explained in greater detail shortly. Oxydrolone’s chemical modifications and chemical structure (including its C17 Alpha Alkylation) makes it very resistant to hepatic breakdown (liver metabolism). The greater resistance a substance has to hepatic breakdown, the more toxicity and strain on the liver will be experienced – and Oxydrolone is notorious for its liver toxicity, and is perhaps regarded as the most liver toxic oral anabolic steroid conventionally available.
Cycles including Oxymetholone are normally of the type that are intended for bulking, strength-gaining, and general overall mass. Oxydrolone cycles are poorly suited for the purpose of cutting, fat loss, pre-contest, or anything of the like. Although Oxydrolone can indeed be used to aid and accelerate in fat loss, it is a poor choice because of its Estrogenic effects, notably water-retention and bloating. This side effect serves to provide the physique with an overall soft and smooth look to it, which blurs, obscures definition, making it difficult to visually gauge fat loss. This is made worse by the fact that Oxydrolone does not convert into Estrogen, and therefore imposes this effect on the user by some as-of-yet-unidentified other means. Therefore, and aromatase inhibitor in this case would not work to reduce the bloating effect.
Oxydrolone cycles are normally composed of Oxydrolone as a kickstarting compound for the first 4 – 6 weeks where it is supplementary to other injectable base compounds that are used for similar purposes, such as Testosterone Enanthate, Deca-Durabolin (Nandrolone Decanoate), Trenbolone Enanthate, etc. It can also be utilized in the middle of a cycle in order to push through any sticking points or plateaus in training progress. Additionally, some users throw it into the end of a cycle in order to boost the end of a cycle and act as a ‘finisher’ compound in a cycle, leaving the user to end off their cycle with some very impressive strength and size gains as they move into the PCT (Post Cycle Therapy) phase.
Oxydrolone cycles should not extend beyond 4 – 6 weeks due to hepatotoxicity issues. However, other compounds used with it, such as injectables, can be utilized beyond Oxydrolone’s ending period.
Because Oxydrolone is most commonly manufactured in 50mg tablets, bodybuilding and athletic purposes call for 25 – 50mg per day for a beginner. Intermediate users are known for using a range of 50 – 100mg per day, and although approaching risky limits, advanced users as high as 150mg per day. Generally, however, most users whether beginner, intermediate, or advanced, should seldom require more than 50mg per day due to the sheer potency and strength of Oxydrolone as an anabolic steroid. This is especially the case when studies have demonstrated that a 100mg Oxydrolone dosage is indeed more effective than a 50mg Oxydrolone dosage, but beyond 100mg the results will be no more effective than 100mg itself, and diminishing returns begin to manifest.
An additional point of interest about Oxydrolone dosages is that many users report a reduction in appetite directly proportional to the dose utilized, and studies have shown that it also increases glucose intolerance and insulin resistance, thus making nutrient use by the body less efficient.
Oxydrolone dosages can and should ideally be split throughout the day so as to ensure stable and steady blood plasma levels of the hormone. Oxydrolone exhibits a half-life of about 8 to 9 hours in the body, and therefore a schedule involving a morning (AM) dose followed by an afternoon/evening (PM) dose is best.